Drug cross‐linking electrospun fiber for effective infected wound healing
نویسندگان
چکیده
The management of infected wounds is still an intractable challenge in clinic. Development antibacterial wound dressing great practical significance for management. Herein, a natural-derived drug, tannic acid (TA), was incorporated into the electrospun polyvinyl alcohol (PVA) fiber (TA/PVA fiber, 952 ± 40 nm diameter). TA worked as cross-linker via hydrogen bonding with PVA to improve physicochemical properties and reach sustained drug release (88% at 48 h). Improved mechanical property (0.8–1.2 MPa) computational simulation validated formation bonds between PVA. Moreover, anti-inflammatory characteristics laid foundation application TA/PVA repairing wounds. Meanwhile, vitro studies proved high hemocompatibility cytocompatibility fiber. Further vivo animal investigation showed that promoted repair by inhibiting bacterial growth, promoting granulation formation, collagen matrix deposition, accelerating angiogenesis, inducing M2 macrophage polarization within 14 days. All data demonstrated cross-linked would be potent bacteria-infected healing.
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ژورنال
عنوان ژورنال: Bioengineering & translational medicine
سال: 2023
ISSN: ['2380-6761']
DOI: https://doi.org/10.1002/btm2.10540